β-淀粉樣蛋白肽(Beta Amyloid Peptide，β-AP)
β淀粉樣蛋白是一種與阿爾茨海默病(AD)有關的蛋白，其在患者大腦中堆積形成的淀粉樣斑塊的蛋白。β淀粉樣肽通常含有39～43 個氨基酸。在神經退行性疾病狀態下，經β分泌酶和γ分泌酶依次酶解淀粉樣前體蛋白（APP：一種 100-140 kDa 的跨膜糖蛋白)而產生的不溶性低聚物，最終導致神經元死亡。由于β-淀粉樣蛋白（Aβ40/42）在AD發病中起關鍵作用，因而成為AD的蛋白免疫療法項目中研究最多的蛋白之一。
Case study I: β-Amyloid (1-40)
Sequence: Asp - Ala - Glu - Phe - Arg - His - Asp -... ... ...- Leu - Met - Val - Gly - Gly - Val - Val
Length: 40 aa
Case study II: β-Amyloid (1-42), Human
Sequence: Asp - Ala - Glu - Phe - Arg - His - Asp -... ... ... - Gly - Gly - Val - Val - Ile - Ala
Length: 42 aa
Case study III: β-Amyloid (25-35)
Sequence: Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met
Length: 11 aa
Related Neuroscience Antibodies:
GenScript offers a wide range of tools, including pan and phospho-specific antibodies and proteins geared toward different areas of neuroscientific research. We have a comprehensive collection of antibodies targeting Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and other neurological diseases.
- Unique Collection: We offer both of phospho-specific antibodies and their non-phospho counterparts.
- Full Coverage: Our products cover several neurological disease pathways.
- Multiple Applications: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, etc.
- Convenience: We offer MiniFresh trial size antibodies available in small packages at minimal cost.
Other Related Products & Services:
- THE™ Elite Antibodies: THE™ stands for THE unmistakable, THE irreplaceable, and THE best quality in the industry. GenScript is proud to present THE™ Elite Antibody series, the most precise and effective antibodies in the market, meeting requirements of even the strictest research.
- Amino Acids Derivatives: Speciality & high quality amino acids for peptide synthesis.
- H1N1 Antibodies: High quality antibodies can be readily employed in the detection of influenza A virus (H1N1) through routine immunoassays.
- Blocking Peptides: GenScript provides blocking peptides for most of our antibodies. These peptides can be used to identify antibody's specific interaction with target antigen, as opposed to non-specific binding.
- ONE-HOUR Western Kits: The ONE-HOUR Western Kits are a series of new products that cut the total procedure time of a Western or dot blot from 4.5 hours to ONE hour with no loss in sensitivity. GenScript's scientists are continuously searching for ways to improve technology and reduce costs. Recently we upgraded to 2nd generation ONE-HOUR Western technology to give you even higher sensitivity and lower background of your Westerns in ONE hour.
- Standard Peptide Synthesis: Our custom peptide synthesis services have a success rate of over 95%. We offer instant online quotations and some of the best prices around.
- Peptide Modification: We offer a comprehensive collection of peptide modification options including but not limited in phosphorylation, MAP, KLH, BSA, and ovalbumin. Our prices are the most competitive in the industry.
- Custom Peptide Libary Services: We have a rapid high-throughput parallel platform, providing custom libraries at very competitive prices. Delivery is guaranteed.
- Custom Antibody Services: Reliable immunological assays demand reliable antibodies. GenScript provides a one-stop solution to all our customers' antibody needs.
- Hye-Jung Kim, Cha-Gyun Jung, Mark A. Jensen, Danuta Dukala, and Betty Soliven. Targeting of Myelin Protein Zero in a Spontaneous Autoimmune Polyneuropathy. J. Immunol. Dec 2008; 181(12): 8753 - 8760
- Chulbul M. Ahmed, Rea Dabelic, Lilian W. Waiboci, Lindsey D. Jager, Linda L. Heron, and Howard M. Johnson. SOCS-1 Mimetics Protect Mice Against Lethal Poxvirus Infection: Identification of a Novel Endogenous Antiviral System. J. Virol. Nov 2008
- Alexander Litovchick and Jack W. Szostak. Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. PNAS. Oct 2008; 105(40): 15293 - 15298
- Jung-Hye Choi, Joon T. Park, Ben Davidson, Patrice J. Morin, Ie-Ming Shih, and Tian-Li Wang. Jagged-1 and Notch3 Juxtacrine Loop Regulates Ovarian Tumor Growth and Adhesion. Cancer Res. Jul 2008; 68(14): 5716 - 5723
- John M. Stafford, Fang Yu, Richard Printz, Alyssa H. Hasty, Larry L. Swift, and Kevin D. Niswender. Central Nervous System Neuropeptide Y Signaling Modulates VLDL Triglyceride Secretion. Diabetes. Jun 2008: 1482 - 1490
- Oliver Soehnlein, Alma Zernecke, Einar E Eriksson, Antonio Gigliotti Rothfuchs, Christine T Pham, Heiko Herwald, Kiril Bidzhekov, Martin E Rottenberg, Christian Weber, and Lennart Lindbom. Neutrophil secretion products pave the way for inflammatory monocytes. Blood. Aug 2008; 112(4): 1461 - 1471